We categorized age into groups of 5 years (i.e., <40, 40–44, 45–49, 50–54, 55–59, 60–64, 65–69, and ≥70 years) with the age-groups collapsed for adequate sample size in the youngest and oldest bins. Further studies are needed to determine whether age-specific diagnostic and treatment criteria would be appropriate. The association of A1C with age was similar when restricted to the subset of FOS subjects with NGT and after adjustments for sex, BMI, fasting glucose, and 2-h postload glucose values.ĬONCLUSIONS-A1C levels are positively associated with age in nondiabetic populations even after exclusion of subjects with IFG and/or IGT. The 97.5th percentiles for A1C were 6.0% and 5.6% for nondiabetic individuals aged <40 years in FOS and NHANES, respectively, compared with 6.6% and 6.2% for individuals aged ≥70 years ( P trend < 0.001). Linear regression revealed 0.014- and 0.010-unit increases in A1C per year in the nondiabetic FOS and NHANES populations, respectively. RESULTS-In the FOS and NHANES cohorts, A1C levels were positively associated with age in nondiabetic subjects. Multivariate analyses were performed, adjusting for sex, BMI, fasting glucose, and 2-h postload glucose values.
In FOS, we examined A1C by age in a subset with NGT, i.e., after excluding those with impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS-We performed cross-sectional analyses of A1C across age categories in 2,473 nondiabetic participants of the Framingham Offspring Study (FOS) and in 3,270 nondiabetic participants from the National Health and Nutrition Examination Survey (NHANES) 2001–2004. We examined whether A1C was associated with age in nondiabetic subjects and in subjects with normal glucose tolerance (NGT) in two population-based cohorts. OBJECTIVE-Although glycemic levels are known to rise with normal aging, the nondiabetic A1C range is not age specific.
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